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Influence of beta-aminoproprionitrile (BAPN) on cell growth and elastic fiber formation in cultures of auricular chondrocytes (1983)

Moskalewski, S. ; Langeveld, C. H. ; Scherft, J. P.

Springer

Cellular and molecular life sciences 39 (1983), S. 1147-1148

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ISSN: 1420-9071

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Auricular chondrocytes isolated from 4-day-old rabbits and grown in vitro for 14 days, proliferated rapidly and produced a conspicuous network of elastic fibers. Beta-aminoproprionitrile (BAPN), which in vivo inhibits cross-linking of elastin, decreased the formation of elastic fibers at a concentration of 10–20 μg/ml and prevented formation at 40 μg/ml. At a concentration of 5 μg/ml only the so-called patches of elastin appeared to be absent. The inhibitory effect of BAPN on cell growth did not exceed 10%, which indicates that BAPN is only slightly harmful to auricular chondrocytes and can safely be used in studies on elastin deposition by these cells in vitro.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01943153

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