ISSN:
1420-9071
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary In isolated mitochondria of heart muscle from rabbits and oxen there is, under suitable conditions, an accumulation of Ca++, which is significantly enhanced by elevating the K+/Na+ quotient of the incubation medium. K-strophanthine (10−5−10−7) does not influence the accumulation of Ca++ by the mitochondria of heart muscle. Therefore the intracellular increase in exchangeable Ca++ observed after digitalis-glycosides could be explained by a decrease of the intracellular K+/Na+ quotient, which is caused by inhibition of the membrane ATPase and diminishes the capacity for Ca++ accumulation in mitochondria.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02144525