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CYTOCHROME P450: Nature's Most Versatile Biological Catalyst (2005)

Coon, Minor J.

Palo Alto, Calif. : Annual Reviews

Annual Review of Pharmacology 45 (2005), S. 1-25

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ISSN: 0362-1642

Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff

Topics: Medicine , Chemistry and Pharmacology

Notes: The author describes studies that led to the resolution and reconstitution of the cytochrome P450 enzyme system in microsomal membranes. The review indicates how purification and characterization of the cytochromes led to rigorous evidence for multiple isoforms of the oxygenases with distinct chemical and physical properties and different but somewhat overlapping substrate specificities. Present knowledge of the individual steps in the P450 and reductase reaction cycles is summarized, including evidence for the generation of multiple functional oxidants that may contribute to the exceptional diversity of the reactions catalyzed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1146/annurev.pharmtox.45.120403.100030

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