Electronic Resource
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Immunology
23 (2005), S. 197-223
ISSN:
0732-0582
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Biology
,
Medicine
Notes:
Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase. We now know this is incorrect. The oxidase pumps electrons into the phagocytic vacuole, thereby inducing a charge across the membrane that must be compensated. The movement of compensating ions produces conditions in the vacuole conducive to microbial killing and digestion by enzymes released into the vacuole from the cytoplasmic granules.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.immunol.23.021704.115653
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