ISSN:
0025-116X
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
Proper reaction conditions were determined for the activation of water-soluble, biocompatible poly[N-(2-hydroxypropyl)methacrylamide] (1) by esterification with 4-nitrophenyl chloroformate (2). The rate constants of hydrolysis and aminolysis of the 4-nitrophenyl ester groups in resulting polymer 3 were compared. It was shown that at pH 8 - 9 the rate of aminolysis in water solutions is high enough for binding bioactive molecules via —NH2 groups. Cobra venom acetylcholinesterase was bound to the activated polymer 3 and thermostability and immunogenicity of this product were studied.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/macp.1983.021840702