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Ciliotoxicity of intranasal formulations: Menthol enantiomers (1993)

Su, Xiang-Yao ; Po, Alain Li Wan ; Millership, Jeffrey S.

New York, NY [u.a.] : Wiley-Blackwell

Chirality 5 (1993), S. 58-60

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ISSN: 0899-0042

Keywords: menthol ; nasal delivery ; adverse effects ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: It is shown, using in vitro measurements of beat frequency of rat tracheal cilia, that (+)-(1S, 2R, 5S)-menthol and (-)-(1R, 2S, 5R)-menthol have equipotent ciliotoxicities despite the fact that inhalation of menthol vapours from the crystals of the pure enantiomers show clearly that the (-)-(1R, 2S, 5R)-menthol produces a more potent cooling sensation. Differential scanning calorimetry demonstrates the formation of a racemic compound when equimolar amounts of the two enantiomers are admixed. © 1993 Wiley-Liss, Inc.

Additional Material: 4 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/chir.530050203

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