ISSN:
0899-0042
Keywords:
chiral LC
;
drug enantiomers
;
modelling
;
central composite desire
;
optimization
;
β-cyclodextrin
;
response surface
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The application of a central composite design to the enantiomeric separation of the antifungal drug tioconazole is investigated. The design involves application of a mathematical model to the data to model the response in regions of the factor space not investigated in the experimental design. The significance of the variable terms in the model is assessed statistically and those terms declared not significant are removed from the model. The statistical adequacy of these reduced models is discussed, together with an examination of the prediction errors of the models. Three-dimensional predicted response surfaces for the complete models are presented and the predictive performance assessed. © 1992 Wiley-Liss, Inc.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.530040510
