ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Thermitase - A Thermostable Serine Protease. II. Synthesis of Substrate Analogous Peptide Chloromethyl Ketones as Irreversibly Acting InhibitorsThe preparation of dipeptide to pentapeptide chloromethyl ketones of alanine wth variation of the amino acid in the P1 and P2 positionNomenklatur für die individuellen Aminosäurereste der Peptide nach I. Schechter u. A. C. Berger, Biochem. Biophys. Res. Commun. 27, 157 (1967). of the peptides is described. The synthesis is performed by fragment condensation of N-acylated amino acids or peptides with the unprotected chloromethyl ketone derivatives of amino acids and peptides, respectively. Some examples of enzyme inactivation by peptide chloromethyl ketones are discussed.
Additional Material:
4 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19843260107
