ISSN:
0020-7608
Keywords:
Computational Chemistry and Molecular Modeling
;
Atomic, Molecular and Optical Physics
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
We have analyzed the dependence of the serotonin receptor binding affinity on the electronic and steric reactivity indexes for a group of 5-substituted tryptamines. The approaches employed are a new nonempirical Quantitative Structure - Activity relationship approach and multiple regression analyses. The results suggest that the variation of the receptor binding affinity in 5-substituted tryptamines is related to the variation of the net charge of two atoms and to the steric bulk of the N-substituent. A receptor model is proposed.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/qua.560280402