ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Following the conventional methodology used for the synthesis of bile pigments, some oxa- and thia-deazabiliverdin analogues were synthetized for the first time. Both UV/VIS spectroscopic and 1H{1H}-NOE difference studies reveal that the oxa-deaza-biliverdin analogue 8a occurs in apolar solvents in a partly ‘stretched’ conformation, whereas the corresponding thia derivative 8b behaves rather like a genuine bile pigment. Unexpectedly, the helical-shaped conformation is also preponderant in a trioxa-trideaza-biliverdin analogue, which could be only characterized in its protonated form 14.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19940770715