ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The CH2Cl2 extract of the leaves Annona purpurea L. (Annonaceae) showed strong brine shrimp toxicity and pronounced activity against larvae of the yellow-fever mosquito Aedes aegypti. Activity-directed fractionation of the extract by a combination of column chromatography on silica gel, filtration, and high-pressure liquid chromatography led to the isolation of acetogenins 1-6 as the main active principles. The structures of two novel acetogenins named purpureacin 1(5) and purpureacin 2(6) were elucidated by spectroscopic analysis (UV, EI- and DCI-MS, EI-MS of Me3Si derivatives,1H- and 13C-NMR). The configuration of 5 and 6 was not established due to the limited sample amount. Compounds 3-6 also showed antifungal activity against Candida albicans, and 5 was slightly active against Bacillus subtilis.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19930760324
