ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A regio- and steroselective conversion of the totally synthetic 3α, 18-di-O-benzyl-17-nor-14-aphidicolen-16-one (5), into (±)-aphidicolin 1, by hydroxylation of the 2-methylidenebicyclo[3.2.1] oct-3-ene derivative 6 is described. Compound 5 was a key intermediate in our previously described total synthesis of 2, which represented a formal synthesis of 1.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19880710423