ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The octahydroisoindolone moiety related to proxiphomin (1) has been synthesized by condensation of N-benzyloxycarbonyl-protected D, L-phenylalaninal (7) with methyl-(4-methyl-sorbyl)-malonate (11) to yield the branched ethylene derivative 12. Consecutive intramolecular [2+4]-cycloaddition and lactam ring closure of 12 gave the desired octahydroisoindolone derivative 15, possessing adaptable functional groups for the attachment of the macrocyclic ring system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19780610616