ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The mechanism of the addition of nucleophiles to alkyne-derivatives 1 having both push- and pull-groups yielding Michael-adducts is investigated. The rate of the second-orderreaction increases (a) with increasing nucleophilic character of the amine and alcohol respectively, (b) with increasing electrophilic character of the alkyne-derivatives 1, and (c) with increasing solvent polarity. These results support as rate-determining step an attack of the nucleophile at C(3) of the alkyne-derivatives.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19730560311