ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The preparative aspects of the addition of nucleophiles to alkyne-derivatives having both push- and pull-groups (1) are discussed: The addition of primary and secondary amines as well of aliphatic alcohols to the alkyne-derivatives 1 in most cases predominantly yields the Michael-adducts 2-10. The importance of a side-reaction consisting in an addition of amines to C(2) of the alkyne-derivatives 1 increases in the series 1c ≪ 1b 〈 1a and is controlled by stereoelectronic effects. The spectroscopic properties of the compounds 2-10 are given.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19730560310