ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Brewer et al. [1] have established sequence I for the first 34 amino acid residues of human parathyroid hormone. It differs in 6 and 5 positions respectively from the corresponding bovine [2] [3] and porcine [4] hormone sequences. The synthesis of the protected tetratriacontapeptide II by the fragment-coupling approach and its purification by counter-current distribution are described. Removal of the protecting groups by acidolysis then gave I in high purity.I displays hypercalcemic activity in the thyroparathyroidectomized rat indicating that the amino terminal part also constitutes the hormonally active region of human parathyroid hormone.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19730560139