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Synthese des «Thyrotropin-releasing» Hormons (TRH) (Schaf) und verwandter Peptide (1970)

Gillessen, D. ; Lergier, W. ; Studer, R. O. ; [et al.]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 53 (1970), S. 63-72

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ISSN: 0018-019X

Keywords: Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The syntheses of seven tripeptide isomers containing L-histidine, L-proline and L-glutamic acid residues, the same as found in the natural thyrotropin-releasing hormone (TRH), are reported. In addition L-pyroglutamyl-L-histidyl-L-proline and its amide as well as Nα-acetyl-L-glutamyl-L-histidyl-L-proline are described. Whereas eight peptides are inactive and L-pyroglutamyl-L-histidyl-L-proline shows a slight TRH activity, L-pyroglutamyl-L-histidyl-L-proline-amide has the full biological activity of the isolated thyrotropin-releasing hormone and, at the present state of knowledge, seems to be identical with it.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/hlca.19700530107

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