ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The selective cleavage of the N-sulphenyl protecting group from amino-acids and peptides containing additional acid-labile protecting residues has been investigated. Among various nucleophilic reagents tested for their ability to effect rapid and specific removal of the N-sulphenyl groups, hydrogen cyanide, sulfurous acid and thioacetamide have been found to be particularly suitable. The application of this method to the solid phase synthesis of peptides is described and discussed.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19660490415