ISSN:
0170-2041
Keywords:
Hemithioacetals, deoxy
;
Calicheamicins
;
Esperamicins
;
Thiodigitoxoside
;
Digitoxoside, 4-thio-
;
Antibiotics, antitumor
;
Antitumor antibiotics
;
Saccharides
;
Carbohydrates
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 4-thio analog of 2,6-dideoxy-D-ribo-hexopyranose (D-digitoxose) is part of the saccharide chain of the calicheamicins and esperamicins. A straightforward synthesis of the 4-thiodigitoxoside 12 as its diacetate 13 starting from methyl α-D-galactopyranoside (1) is described. Properties and structure of 13 are presented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199319930133