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Asymmetric Synthesis of 1,4-Disubstituted Tetrahydroioquinolines (2000)

Jullian, Valerie ; Quirion, Jean-Charles ; Husson, Henri-Philippe

Weinheim : Wiley-Blackwell

Liebigs Annalen 2000 (2000), S. 1319-1325

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ISSN: 1434-193X

Keywords: Asymmetric synthesis ; Tetrahydroisoquinolines ; Cyclizations ; Diastereoselective alkylation of Amides ; Phenylglycinol ; Chemistry ; General Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: -Bischler-Napieralski cyclisation of optically active β-substituted phenylethylamines 4a-c followed by diastereoselective reduction led to 1,4-disubstituted tetrahydroisoquinolines 6a-c and 8a-c. The same methodology afforded the 4-benzyl pyrroloisoquinolines 10.

Type of Medium: Electronic Resource

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