ISSN:
0009-2940
Keywords:
Enantiomerization
;
Dynamic complexation gas chromatography
;
Homofuran
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
By computer simulation of experimental interconversion profiles, obtained by complexation gas chromatography, rate constants of enantiomerization have been determined for homofuran between 95 and 130°C. Since enantiomerization proceeds at similar rates in the mobile and stationary phase, the rate constants obtained by an Arrhenius plot are in excellent agreement with values determined independently by polarimetry between 60 and 90°C. We thus demonstrate that dynamic chromatography can be an easy means for the rapid determination of enantiomerization (or isomerization) barriers of ca. 70-120 kJ mol-1 requiring only minute amounts of racemic sample.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19921250543