ISSN:
0009-2940
Keywords:
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The reaction of ZnO or ZnCO3 with L-aspartic acid yields zinc di(L-aspartate), wherein aspartic acid (L-AspH2) functions as a monobasic acid: Zn(L-AspH)2. This precursor reacts with one equivalent of ZnCl2 in aqueous solution at pH=4.25 to give the title compound Zn(L-AspH)Cl, which contains no water of crystallisation (solubility: 12.8% [w/w] at 22°C). The X-ray structure analysis shows the zinc atoms to be tetrahedrally surrounded by a chloride ion and three oxygen atoms of carboxylate groups originating from three different L-AspH anions. This constitution is fundamentally different from that of the magnesium analogue, but also of the corresponding halide-free aspartates and glutamates of zinc and cadmium. The results may be of some significance for pharmacological cooperativity phenomena (chloride/aspartate) in metal complexation.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19871200531
