ISSN:
0009-2940
Keywords:
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Studies in the Synthesis of the Antibiotics Gliotoxin, Sporidesmin, Aranotin, and Chaetocin, IV. Preparation of Epidithio-L-prolyl-L-proline AnhydrideRepeated research of the electrophilic introduction of sulfur functions into the -3 and 6-positions of 2.5-dioxopiperazines leads to the preparation of the amorphous epioligothio-L-prolyl-L-proline anhydride (7). The latter could be reduced and consequently dehydrogenated forming epidithio-L-prolyl-L-proline anhydride (8) which corresponds in conformation and configuration to the naturally occurring antiviral antibiotics.
Notes:
Erneute Untersuchung der elektrophilen Einführung von Schwefelfunktionen in den Dioxopiperazinkern führte zur Synthese eines amorphen Epioligothio-L-prolyl-L-prolinanhydrids (7). Aus diesem wurde durch Reduktion und folgende Dehydrierung Epidithio-L-prolyl-L-prolinanhydrid (8) gebildet, das in der Konformation und Konfiguration den natürlichen antiviralen Antibiotika entspricht.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19721050229
