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Photo-reversal of the circadian rhythm in the proliferative activity of the mouse small intestine (1971)

Sigdestad, Curtis P. ; Lesher, S.

New York, NY [u.a.] : Wiley-Blackwell

Journal of Cellular Physiology 78 (1971), S. 121-125

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ISSN: 0021-9541

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: Mice (C57Bl) were placed for 35 days in a room with reversed light cycle; lights came on at 1800 hours and off at 0600 hours. At six hour intervals throughout the day three mice were injected with tritiated thymidine and sacrificed 30 minutes later. Crypts were dissected for radioautography and determination of disintegrations per minute per crypt, the number of cells in mitosis and the number of cells synthesizing DNA was determined. The results reported clearly demonstrate reversal of the circadian rhythm in the parameters tested.

Additional Material: 3 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/jcp.1040780115

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