ISSN:
0021-9304
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
We examined the formation of platelet aggregate emboli and factors that affect platelet aggregate formation and embolization in prototype hollow-fiber membrane oxygenators used to perfuse dogs. Platelet aggregates formed on the inlet surface of the oxygenator. Many aggregates subsequently formed emboli which passed through the fibers and sometimes lodges in them. Aggregates also developed on the outlet surface. Aggregates that adhered to the oxygenator surfaces contained tightly packed platelets having multiple pseudopodia extracellular granules, and occassional fibrin strands and white cells. The number of platelet aggregate emboli found downstream to the oxygenator varied between 0 and 4 emboli/ml blood. These emboli did not contain fibrin and extracellular granules. Platelet aggregate formation and embolization was reduced or eliminated by increasing the dose of heparin or by using a circuit with a large priming volume of albumin solution and a large surface area oxygenator.
Additional Material:
12 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jbm.820080206
