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Human restriction fragment length polymorphisms and cancer risk assessment (1986)

Krontiris, Theodore G. ; DiMartino, Nancy A. ; Colb, Mark ; [et al.]

New York, N.Y. : Wiley-Blackwell

Journal of Cellular Biochemistry 30 (1986), S. 319-329

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ISSN: 0730-2312

Keywords: oncogenes ; Ha-ras ; restriction fragment length polymorphism ; human genetics ; cancer risk assessment ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: The polymorphic restriction fragments of the human Ha-ras locus, produced by the variable tandem repetition (VTR) of a short consensus sequence, fall into three classes based on allelic frequencies. Alleles of the “rare” class (individual frequencies 〈 0.5%) have been detected only in white blood cell and tumor DNA of cancer patients. This phenomenon is independent of ethnic origin. No significant association of rare alleles with cancer patients has been demonstrated at an independent tandem repeat locus, VTR4.1. The results suggest that the Ha-ras restriction fragment length polymorphism is useful in cancer risk assessment.

Additional Material: 3 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/jcb.240300405

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