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High-throughput screening of historic collections: Observations on file size, biological targets, and file diversity (1998)

Spencer, Robin W.

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 61 (1998), S. 61-67

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ISSN: 0006-3592

Keywords: high-throughput screening ; compound collection ; data quality ; biological targets ; protein-protein interactions ; file clustering and diversity ; Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: At Pfizer Central Research, high-throughput screening has been an important source of new leads for drug discovery for a decade. Our experience with over 150 high-throughput screens can address questions about necessary file size, how well particular biological targets fare (with particular reference to protein-protein interactions), and what file diversity means in practice. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng (Comb Chem) 61:61-67, 1998.

Additional Material: 9 Ill.

Type of Medium: Electronic Resource

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