ISSN:
0006-3592
Keywords:
β-amino ester
;
quinoline derivatives
;
Ln(OTf)3
;
three-component reactions
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
A convenient method for library construction in liquid phase, which is based on lanthanide triflate (Ln(OTf)3)-catalyzed three-component reactions, has been developed. Equimolar amounts of each component, an aldehyde, an amine, and a silyl enol ether or an alkene, react smoothly in the presence of Ln(OTf)3, and the work-up and purification processes are performed by simply passing through a short column. The key is to use Ln(OTf)3 as a Lewis acid catalyst, which is not decomposed during the work-up and purification steps, and is easily separated from products by the simple procedure. According to this method, various high-quality β-amino ester and quinoline derivatives have been prepared in parallel in large quantities. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng (Comb Chem) 61:23-31, 1998.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
