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Ala analogues of the cyclolinopeptide A (1989)

Zanotti, Giancarlo ; Tancredi, Teodorico ; Rossi, Filomena ; [et al.]

New York : Wiley-Blackwell

Biopolymers 28 (1989), S. 371-383

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ISSN: 0006-3525

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Analogues of cyclolinopeptide A, due to the replacement of each amino acid in the Pro1-Pro2-Phe3-Phe4 sequences with an L-Ala residue, were synthesized by classical method in solution. Mixed anhydride and N,N′-dicyclohexylcarbodiimide coupling methods have been used for the synthesis of both linear and cyclic peptides. The products were characterized by Rf values and uv spectra, as well as by fast atom bombardment spectroscopy.1H-nmr studies on [Ala2] analogues are also reported. Preliminary data in CDCI3 solution, at low temperature, seems more promising.

Additional Material: 3 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/bip.360280135

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