ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The interaction between cyclic peptides [cyclo-(Sar4), cyclo-(Pro-Sar-Gly)2, cyclo-(Sar-Sar), and cyclo-(Sar-Gly)] with benzene has been investigated by nmr spectroscopy. The experiment with cyclo-(Sar4) showed that benzene interacted preferentially with the trans peptide bond in a similar manner to the dimethylformamide-benzene interaction. The solvent-induced nmr shift was then applied to the conformational analysis of cyclo-(Pro-Sar-Gly)2 with the aid of the molecular model. The major conformation was proved to possess the C2 symmetry with internally hydrogen-bonded glycine residues, in which all peptide bonds were trans. The interaction of cyclo-(Sar-Sar) and cyclo-(Sar-Gly) with benzene was also studied. The association constant was 0.115-kg solution per mole of cyclo-(Sar-Sar) and 0.089-kg solution per mole of cyclo-(Sar-Gly) in chloroform.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1975.360140406