ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The optical rotatory dispersion of copolymers of O-carbobenzoxy-L-tyrosine and benzyl L (or D)-glutamate as well as benzyl L-aspartate, dissolved in nonpolar solvent, has been studied. Moffitt's equation permits the determination of b0 coefficients whose variation, with varying composition in amino acid residues, suggests that the molecules of poly-O-carbobenzoxy-L-tyrosine have a helical structure similar to that of poly-(benzyl L-glutamate). Results obtained from infrared spectroscopy and x-ray diffraction show that the copolymers possess a helical conformation in the solid state, even when they are very rich in carbobenzoxy-L-tyrosine residues. The value of the b0, coefficient for poly-O-carbobenzoxy-L-tyrosine may be explained by a regular stacking of the chromophore groups around the helical backbone. The ordering of the molecules of this polymer in a purely helical structure seems favored by the insertion of a small number of foreign residues in the polypeptide chain.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1967.360050403
