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Quantitative determination of erythromycin 2′-ethylsuccinate in human plasma by fast atom bombardment mass spectrometry (1987)

Ottoila, Pekka ; Taskinen, Jyrki

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 14 (1987), S. 659-662

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ISSN: 0887-6134

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A method for simultaneous quantitative determination of erythromycin 2′-ethylsuccinate and erythromycin in human plasma is described. After extracting the deuterium-labelled internal standards and analytes from alkalinized plasma to diethyl ether the extracts were analysed by fast atom bombardment mass spectrometry. The quantification limit for 2′-ethylsuccinate ester was 50 ng ml-1 and for erythromycin 100 ng ml-1. The calibration curves were linear up to 5 μg ml-1 for both. The precision of the method at higher concentration was less than 2% and at the quantification limit ∼6% for both analytes.

Additional Material: 5 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/bms.1200141116

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