ISSN:
0749-1581
Keywords:
steroids
;
1H NMR
;
13C NMR
;
coupling constants
;
conformational analysis
;
1D TOCSY
;
NOE
;
cyclosteroids
;
cyclopropanosteroids
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Proton and carbon NMR data are provided for 21 ring A and ring B cyclosteroids and cyclopropano (or methylene) steroids. Shift assignments were made using standard 2D NMR techniques, while ring A proton subspectra were extracted with a 1D TOCSY experiment. Coupling constants were obtained from iterative spin system simulation of these sub-spectra. Ring A conformations were determined from the two- and three-bond proton-proton couplings and NOE measurements. The utility and limitations of extended Karplus-type equations, the effect of cyclopropyl groups on vicinal and geminal couplings and cyclopropane-induced chemical shifts are discussed.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260330707
