ISSN:
0030-493X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The distinction between 17-epimeric 3,17-dioxygenated hydroxyandrostanes has been made by comparison of both their methane or ammonia positive and OH- negative chemical ionization (CI) mass spectra. In the methane or ammonia positive CI, the 17α-configuration in the eight stereoisomeric 5ξ-androstane-3ξ,17ξ-diols can be determined by the relative abundances of the ion [MH—2 H2O]+. In the ammonia CI spectra, the ion [M+NH4—H2O]+ possesses only a low abundance, but a comparison of the relative rates of the loss of water v. the loss of ammonia from [M.NH4]+ in the second field-free region allows a clear distinction to be made between the 17α- and 17β-series. In the OH- negative CI mass spectra, the 5ξ-androstane-3-one-17ξ-ols produce an intense ion [M—H—H2O]- in the 17α-series only.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/oms.1210200808
