ISSN:
0935-6304
Keywords:
Fragrances
;
chirality evaluation
;
semi-automated multidimensional gas chromatography
;
infrared spectrometry
;
mass spectrometry
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
---The use of a semi-automated, multidimensional gas chromatography (MDGC) Fourier transform infrared (FT-IR) mass spectrometry (MS) system in the determination of components causing contact dermatitis has been investigated. Fragrances are widely used in cosmetic and household products and are the leading cause of contact dermatitis. Such products contain numerous components such as emulsifiers, thickeners, solubilizers, pigments, antioxidants, and many other compounds, which can make it difficult to isolate the compound of interest. MDGC has the capability for component analysis in such complex matrices. A semi-automated MDGC system, which consists of a commercial instrument modified in our laboratory to include two computer controlled valves and a single trap which is manually controlled was evaluated for analysis of irritants in a total of thirteen soaps. Using heartcutting techniques, components causing dermatitis were identified in eight of the thirteen soaps by examining both the infrared and mass spectra obtained and matching them with computer spectral libraries. Results from these analyses show that a baby soap and three other mild soaps were free of irritants. Irritants were identified in the remaining eight soaps. In addition, to demonstrate the versatility of the semi-automated system, the enantiomeric composition of a chiral irritant in two soaps also was determined.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
