ISSN:
0935-6304
Keywords:
Capillary GC
;
Derivatization
;
(Chloro)alkyl chloroformates
;
Non-aqueous reaction media
;
Aqueous reaction media
;
Fatty acids
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Fatty acids can be conveniently derivatized in less than one minute with (chloro)alkyl chloroformates such as methyl chloroformate, 2-chloroethyl chloroformate and 2,2,2-trichloroethyl chloroformate. 2,2,2-Trichloroethyl chloroformate is the most reactive reagent, and yields a reaction product which can be sensitively detected by GC ECD (detection limit 50 ng/ml, i.e. 25 pg/injection, for C8, C10, and C12 acids).In non-aqueous media 3-picoline, N-methylpiperidine, and dimethylaminopyridine show catalytic activity comparable with that of pyridine and can, therefore, replace it. N-methylpiperidine is the best basic catalyst in aqueous media (i.e. media containing up to 40 % water).
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240151203
