Publication Date:
2021-05-19
Description:
Nonylphenol (NP) is an endocrine disrupting chemical which has been shown to be able
tomodulate endocrine system of various organisms by different mechanisms. The
objective of this study was to investigate the potential effects of 4-NP and 17-β -
estradiol (E2) on the immune parameters (IgM levels and lysozyme activity) of the
teleost Koi carp (Cyprinus carpio carpio) for a better understanding of the immunereproductive
system interactions. The experimental fishes were injected with ascending
doses (10, 50,100 μgg^-1
body weight) of 4- nonylphenol (4-NP) and (2 μgg^-1
body mass)
of 17-β-estradiol (E2) or vehicle during 3 weeks. After 21 days, the fishes (180) were
anesthetizedand their blood samples were collected from caudal vein, then they were
dissected and sexually separated by gonad characters. The measurement of immune
parameters in plasma showed that 4-NP induced significant increase in the IgM levels
and lysozyme activity at dose of 50 μgg^-1 while the levels of these parameters in the
higher doses (100 μgg^-1
) decreased compared with the control group (p〈0.05). In
addition the treatment, with 2 μgg^-1 E2 significantly decreased both the IgM levels and
lysozyme activity after 21 days of injection. These results indicated that 4-NP and E2
could lead to disturb the balance of immune system with potential consequences for
immature koi carp.
Description:
Published
Keywords:
4-nonylphenol
;
17-β-estradiol
;
Immune-reproductivesystem
;
Immunoglobulin IgM
;
Lysozyme
;
Koi carp
;
Cyprinus carpio carpio
;
Disruption
;
Growth performance
;
Female
;
Male
Repository Name:
AquaDocs
Type:
Journal Contribution
,
Refereed
Format:
pp.725-744