Publication Date:
2023-02-02
Description:
Advanced Blood-Brain Barrier Drug Delivery is a reprint with a summary editorial, followed by 16 chapters that cover five areas of brain drug delivery, including receptor-mediated transport (RMT), carrier-mediated transport (CMT), active efflux transport (AET), Trojan horse lipid nanoparticles (LNP), and in vivo methods for measurement of drug transport across the blood–brain barrier (BBB).
Keywords:
blood–brain barrier (BBB)
;
brain drug delivery
;
prodrugs
;
solute carriers (SLCs)
;
lysosomal storage disease
;
neuronopathic mucopolysaccharidosis
;
blood–brain barrier
;
neurodegeneration
;
enzyme replacement therapy
;
receptor-mediated transcytosis
;
transferrin receptor
;
insulin receptor
;
endothelium
;
receptor-mediated transport
;
carrier-mediated transport
;
genetic engineering
;
IgG fusion proteins
;
nanoparticles
;
liposomes
;
TrkB
;
agonist antibody
;
variable new antigen receptor (VNAR)
;
neuroprotection
;
transferrin receptor 1 (TfR1)
;
blood-brain barrier (BBB)
;
6-OHDA
;
Parkinson’s disease
;
bispecific antibody
;
alpha-synuclein (αSYN)
;
Parkinson’s disease (PD)
;
immunotherapy
;
monoclonal antibody
;
transferrin receptor (TfR)
;
receptor-mediated transcytosis (RMT)
;
single domains antibody
;
IGF1R
;
neurotensin
;
protein-based therapy
;
lysosomal storage disorders
;
fusion proteins
;
Alzheimer’s disease
;
neurotrophic factors
;
decoy receptors
;
ATP-binding cassette transporters
;
drug delivery
;
ischemic stroke
;
SLC transporters
;
lipid nanoparticle
;
ssPalm
;
mRNA transfection
;
hCMEC/D3 cells
;
cell toxicity
;
SWATH-MS
;
translation
;
chaperonin-containing TCP-1
;
proton-coupled organic cation antiporter
;
photo-affinity labeling
;
proteomics
;
SWATH-MS (sequential window acquisition of all theoretical-mass spectra)
;
pharmacokinetics
;
compartmental models
;
physiologically based PK models
;
blood-brain barrier
;
antibody
;
cavernous sinus
;
BBB–peptide shuttle
;
brain delivery
;
solute carrier (SLC) transporters
;
amyotrophic lateral sclerosis (ALS)
;
NSC-34 cell lines
;
taurine transporter (Taut)
;
large amino acid transporter 1 (LAT1)
;
monocarboxylate transporters (MCTs)
;
organic cation transporters (OCTNs)
;
choline transporter-like protein-1 (CTL1)
;
TNF-α inhibitor
;
molecular Trojan horse
;
endosomal
;
liposome
;
nanoparticle
;
targeting
;
transferrin
;
n/a
;
bic Book Industry Communication::M Medicine
;
bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
Language:
English
Format:
image/jpeg
