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MDPI - Multidisciplinary Digital Publishing Institute
Publication Date:
2022-11-17
Description:
This Special Issue of Viruses focuses on the topic of viruses and nuclear egress. Nuclear egress is a fascinating process by which herpesvirus nucleocapsids make their way from the nuclear interior to the cytoplasm. As nuclear egress and the viral proteins that orchestrate it differ from host processes and proteins in important ways, there is interest in targeting antiviral therapies to disrupt this process. Indeed, the recently approved drug maribavir acts in large part by inhibiting a step of nuclear egress. The Special Issue includes five reviews—three on nuclear egress of two alphaherpesviruses, herpes simplex virus and pseudorabies virus; one on a betaherpevirus, human cytomegalovirus; and one on a gammaherpesvirus, Epstein–Barr virus—and five research papers—two on alphaherpesviruses and three on human cytomegalovirus.
Keywords:
human cytomegalovirus
;
core nuclear egress complex
;
ORF-UL50 deletion
;
pUL50 phosphosite mutants
;
phenotypical changes
;
differential functional relevance
;
Epstein–Barr virus
;
BGLF4 kinase
;
nuclear egress
;
BFRF1
;
nuclear envelope modulation
;
herpesviruses
;
primary envelopment
;
de-envelopment
;
herpesvirus
;
pseudorabies virus
;
PrV
;
vesicle-associated membrane protein associated protein
;
VAPA
;
VAPB
;
CRISPR/Cas9 genome editing
;
enveloped virus budding
;
ESCRT
;
membrane scission
;
HSV1
;
pUL34
;
pUL31
;
NEC
;
targeting integral membrane proteins
;
TA membrane proteins
;
inner nuclear membrane (INM)
;
nuclear import
;
importins
;
n/a
;
CMV
;
peptide therapy
;
tegument
;
phosphorylation
;
nuclear envelopment complex
;
membrane fusion
;
hemi-fusion
;
virus assembly
;
virus–cell interactions
;
capsid migration
;
UL53
;
UL50
;
myosin Va
;
major capsid protein
;
mass spectrometry
;
virus genetics
;
complementing cells
;
null mutants
;
bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
;
bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
;
bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSG Microbiology (non-medical)
Language:
English
Format:
image/jpeg
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