Publication Date:
1993-01-15
Description:
Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of messenger RNA for the constitutive form of heme oxygenase throughout the brain has been demonstrated. This localization is essentially the same as that for soluble guanylyl cyclase messenger RNA. In primary cultures of olfactory neurons, zinc protoporphyrin-9, a potent selective inhibitor of heme oxygenase, depletes endogenous guanosine 3',5'-monophosphate (cGMP). Thus, carbon monoxide, like nitric oxide, may be a physiologic regulator of cGMP. These findings, together with the neuronal localizations of heme oxygenase, suggest that carbon monoxide may function as a neurotransmitter.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Verma, A -- Hirsch, D J -- Glatt, C E -- Ronnett, G V -- Snyder, S H -- DA00266/DA/NIDA NIH HHS/ -- MH18501/MH/NIMH NIH HHS/ -- NS02131/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1993 Jan 15;259(5093):381-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Walter Reed Army Medical Center, Washington, DC 20307.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7678352" target="_blank"〉PubMed〈/a〉
Keywords:
5-Aminolevulinate Synthetase/analysis/genetics
;
Amino Acid Oxidoreductases/analysis/genetics
;
Animals
;
Animals, Newborn
;
Base Sequence
;
Brain/*enzymology
;
Carbon Monoxide/*metabolism
;
Cells, Cultured
;
Cyclic GMP/*metabolism
;
Guanylate Cyclase/analysis/genetics
;
Heme Oxygenase (Decyclizing)/*analysis/genetics
;
In Situ Hybridization
;
Molecular Sequence Data
;
NADPH-Ferrihemoprotein Reductase/analysis/genetics
;
Neurons/*enzymology
;
Neurotransmitter Agents/*metabolism
;
Nitric Oxide Synthase
;
Oligodeoxyribonucleotides/chemistry
;
RNA, Messenger/analysis
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
