Publikationsdatum:
2004-11-30
Beschreibung:
The actions of many extracellular stimuli are elicited by complexes of cell surface receptors, heterotrimeric guanine nucleotide-binding proteins (G proteins), and mitogen-activated protein (MAP) kinase complexes. Analysis of haploid yeast cells and their response to peptide mating pheromones has produced important advances in our understanding of G protein and MAP kinase signaling mechanisms. Many of the components, their interrelationships, and their regulators were first identified in yeast. Current analysis of the pheromone response pathway (see the Connections Maps at Science's Signal Transduction Knowledge Environment) will benefit from new and powerful genomic, proteomic, and computational approaches that will likely reveal additional general principles that are applicable to more complex organisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Yuqi -- Dohlman, Henrik G -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1508-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567849" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Cell Cycle
;
GTP-Binding Proteins/metabolism
;
Lipoproteins/*metabolism
;
*MAP Kinase Signaling System
;
Mutation
;
Pheromones/*metabolism
;
Phosphorylation
;
Protein Precursors/*metabolism
;
Saccharomyces cerevisiae/genetics/*metabolism/physiology
;
Saccharomyces cerevisiae Proteins/*metabolism
;
*Signal Transduction
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
