Publication Date:
2001-09-15
Description:
Transcription factor TFIID, composed of TBP and TAFII subunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary. Female mice lacking TAFII105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAFII105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient ovaries. Together, these studies suggest that TAFII105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAFII105 as a cell type-specific component of the mammalian transcriptional machinery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freiman, R N -- Albright, S R -- Zheng, S -- Sha, W C -- Hammer, R E -- Tjian, R -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2084-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720-3204, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11557891" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
DNA-Binding Proteins/genetics/*metabolism
;
Down-Regulation
;
Female
;
Gene Expression Profiling
;
Gene Expression Regulation, Developmental
;
Granulosa Cells/metabolism/*physiology
;
In Situ Hybridization
;
Infertility, Female
;
Male
;
Mice
;
Mice, Knockout
;
Oligonucleotide Array Sequence Analysis
;
Organ Size
;
Organ Specificity
;
Ovarian Follicle/*growth & development
;
Ovary/cytology/growth & development/metabolism/*physiology
;
Ovulation
;
Protein Subunits
;
Signal Transduction
;
*TATA-Binding Protein Associated Factors
;
Transcription Factor TFIID
;
Transcription Factors/genetics/*metabolism
;
Transcription Factors, TFII/metabolism
;
*Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
