Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉The RNA-binding protein ALYREF functions in coupling nuclear export and 3'-end processing of polyadenylated mRNAs. New data identify a parallel mechanism for ALYREF also linking 3'-end processing to nuclear export of non-polyadenylated, replication-dependent histone mRNAs.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉ALYREF prevalently binds to a 3' region of histone mRNAs in an SLBP-dependent manner.〈/p〉〈/li〉
〈li〉〈p〉ALYREF promotes histone pre-mRNA processing by ensuring U7-snRNP recruitment.〈/p〉〈/li〉
〈li〉〈p〉The TREX complex facilitates histone mRNA export by recruiting NXF1.〈/p〉〈/li〉
〈li〉〈p〉3'-end processing promotes ALYREF recruitment and histone mRNA export.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine