Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
International journal of immunogenetics
2 (1975), S. 0
ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
The immunogenicity of Thy-1 antigens was examined using the Thy-1 congenic mouse strains A and A/Thy-1.1. A disequilibrium of response was found between these strains. A strain mice rejected skin grafts and produced high titres of antibody to lymphoid cells from A/Thy-1.1 strain mice. However, in the reverse combination grafts were not rejected nor was there any significant antibody response. A/Thy-1.1 mice did not respond to Thy-1.2 antigen when it was presented on an H-2 allogeneic background (A·SW strain) but did respond to it when non-H-2 incompatibilities were involved (B10·A strain donor). We postulate the existence of Ir gene(s) for the response to Thy-1.2 antigens which are linked to H-2. The failure of A/Thy-1.1 strain mice to respond to Thy-1.2 antigens in the absence of carrier determinants is the result of a deletion (in the germ line) of the appropriate Ir gene itself resulting from the long association of the H-2a haplotype of the A mouse (donor of the genetic background of A/Thy-1.1 strain) with the Thy-1.2 gene.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1975.tb00526.x
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