ISSN:
0749-1581
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 1H NMR chemical shifts and spin-spin coupling constants of phenylalanylphenylalanine (Phe-Phe) dipeptide diastereomers have been completely analysed at 100 MHz. Assignment of the observed signals to individual residue protons is proposed, based on characteristic shifts and standard double resonance experiments. The rotamer populations have also been determined. The spectra of the aromatic regions of the dipeptidyl diastereomers, L-Phe-L-Phe and L-Phe-D-Phe, are very different at pH 1.95 in D2O but similar at pH 9.15 in CD3CN—D2O (34:66). These results are correlated with the retention behaviour on a C18 reversed-phase HPLC column.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260230609
