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Pentoxifylline attenuates acute lung injury induced by microemboli (1995)

Shen, C. -Y. ; Hsu, K. ; Wang, D. ; [et al.]

Springer

Cellular and molecular life sciences 51 (1995), S. 956-960

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ISSN: 1420-9071

Keywords: Pentoxifylline ; microemboli ; lung injury

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract Pentoxifylline (PTX), a methylxanthine derivative, effectively prevents acute lung injury in different animal models. To investigate whether PTX would attenuate acute lung injury induced by microemboli resulting from treatment with calcium chloride (CaCl2) suspension, an isolated blood-perfused rat lung model was used. Pretreatment with PTX prevented the increase in pulmonary arterial pressure (PAP), lung weight gain and protein concentration in the lavage fluid after CaCl2 treatment.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01921747

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