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Extraadrenal adrenaline formation by two separate enzymes (1989)

Ziegler, M. G. ; Kennedy, B. ; Elayan, H.

Springer

Cellular and molecular life sciences 45 (1989), S. 718-720

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ISSN: 1420-9071

Keywords: Adrenaline ; epinephrine ; phenylethanolamine-N-methyltransferase ; PNMT ; epinine

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Adrenaline (A) is synthesized in the adrenal medullae by the enzyme phenylethanolamine-N-methyltransferase (PNMT). After surgical removal of the adrenal medullae tissue A levels ranged from 22% of control in the heart to 125% of control in the liver. Use of a novel assay to measure tissue A formation revealed that many tissues can synthesize A using PNMT and another enzyme that N-methylates both noradrenaline and dopamine. These enzymes are non-neuronal, inducible and synthesize a major fraction of tissue and urine A.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01974566

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