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  • 1
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The course of cholesterol-7α-hydroxylase activity was observed for 14 days in 3 groups of rats on 20% fat diets which were of different fatty acid compositions. Determinations were done at 09.00 and 23.00 hr. In the controls the circadian variations of the enzyme were confirmed. Feeding of saturated fatty acids lead to a reduced 7α-hydroxylation of cholesterol in the dark period, whereas feeding of polyunsaturated fatty acids (13% as well as 56% of total fatty acids) showed an enzyme activity unchanged in the dark period but slightly enhanced in the light period.
    Notes: Zusammenfassung Der Verlauf der Cholesterin-7α-Hydroxylase-Aktivität wurde während 14 Tagen an 3 Gruppen fettreich (20%) ernährter Ratten beobachtet (Messungen jeweils um 9.00 und 23.00 Uhr), wobei die einzelnen Diäten sich in der Fettsäurenzusammensetzung unterschieden. Während die Werte der Kontrollgruppe den Circadianrhythmus des untersuchten Enzyms bestätigten, führt Ernährung mit gesättigten Fettsäuren zu einem Absinken der 7α-Hydroxylierung des Cholesterins in der Dunkelphase. Dagegen weisen die Diäten mit polyungesättigten Fettsäuren (13% bzw. 56% des Fettsäurengehaltes) in der Dunkelphase unveränderte, in der Hellphase eher erhöhte Cholesterin-7α-Hydroxylase-Aktivität auf.
    Type of Medium: Electronic Resource
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