Publication Date:
2019
Description:
〈h3〉Abstract〈/h3〉
〈p〉In the era of nanotechnology, nanoparticles (NPs) of metals and metal oxides/chalcogenides are widely been used in medical applications where antibiotic-resistant microorganisms become a serious threat to the human health. Cobalt ferrite (CoFe〈sub〉2〈/sub〉O〈sub〉4〈/sub〉) NPs, synthesized by a simple and cost-effective sol–gel auto-combustion method are envisaged for in vitro antimicrobial activities against Gram-positive bacteria (〈em〉Bacillus subtilis; Staphylococcus aureus〈/em〉) and Gram-negative bacteria (〈em〉Escherichia coli; Pseudomonas aeruginosa〈/em〉). The structure, morphology, elemental analyses and surface area of CoFe〈sub〉2〈/sub〉O〈sub〉4〈/sub〉 NPs are initially screened. The antimicrobial efficiency of CoFe〈sub〉2〈/sub〉O〈sub〉4〈/sub〉 NPs is found to be optimum against the Gram-negative bacteria 〈em〉Escherichia coli〈/em〉 (15 mm). In addition, membrane leakage assays performed to evaluate the intracellular cytoplasmic leakage with CoFe〈sub〉2〈/sub〉O〈sub〉4〈/sub〉 NPs demonstrate the ability to destroy the bacterial membrane integrity, confirming their antimicrobial potential.〈/p〉
Print ISSN:
2008-9295
Electronic ISSN:
2228-5326
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
