Publication Date:
2015-04-24
Description:
by Domenico Cozzolino, Anna Grandone, Antonio Cittadini, Giuseppe Palmiero, Giovanni Esposito, Annamaria De Bellis, Raffaello Furlan, Silverio Perrotta, Laura Perrone, Daniele Torella, Emanuele Miraglia del Giudice Background The prevalence of obesity is increasing among children/adolescents. Subtle cardiovascular abnormalities, responsible for a higher mortality later in life, have been reported in obese children/adolescents. The aims of the study were to evaluate cardiovascular autonomic regulation, by means of spectrum analysis of R-R interval variability, and myocardial function, by means of standard and tissue Doppler echocardiography, in a group of non-hypertensive asymptomatic obese children and adolescents; furthermore, the influence of insulin resistance was tested. Subjects and Methods R-R interval variability was analyzed during both the 70° head-up tilt and 24-hour electrocardiographic holter monitoring. Spectrum analysis of R-R interval variability provided the indices of sympathetic (low frequency [LF RR ]) and vagal (high frequency [HF RR ]) modulation of the sinoatrial node. Homeostasis model assessment of insulin resistance (HOMA-IR) was used to classify obese children/adolescents (n=72) as insulin resistant (n=37) and non-insulin resistant (n=35). Results In obese subjects: a) left ventricular mass was significantly (p
Electronic ISSN:
1932-6203
Topics:
Medicine
,
Natural Sciences in General
